Top 5 weight loss supplements for 2025
In 2025, the science of metabolism has reached a new stage. Innovative weight loss treatments are no longer limited to restrictive diets or dubious pills. Here are the 5 most promising and effective supplements for lasting weight loss, validated by clinical studies and used by thousands of people worldwide.
1. Tirzepatide
Tirzepatide is a dual GIP/GLP-1 agonist, originally developed for type 2 diabetes. It has demonstrated impressive results in weight loss, with up to 22% body mass reduction in some clinical trials.
- Acts on appetite, blood sugar and metabolism
- A weekly injection
- Ideal for severe obesity or cases of metabolic resistance
2. Retatrutide
A new-generation triple agonist (GLP-1, GIP and Glucagon), Retatrutide combines several mechanisms to maximize weight loss while preserving muscle mass.
- Fast, targeted fat loss
- Acts on energy, satiety and lipid combustion
- Still in the evaluation phase, but very promising results
3. Tesofensine
Little-known to the general public, Tesofensine is a dopamine, serotonin and noradrenalin reuptake inhibitor. It acts on the brain to drastically reduce appetite while stimulating energy expenditure.
- Fast appetite suppressant
- Can be taken orally
- Particularly useful for uncontrolled cravings
4. Semaglutide
Under the names Ozempic or Wegovy, Semaglutide is now a must-have. This GLP-1 mimics a natural hormone and acts by slowing digestion and reducing hunger.
- Moderate to high weight loss depending on dosage
- Very well tolerated over the long term
- Perfect for overweight people starting a protocol
5. SLU-PP-332
SLU-PP-332 is an experimental metabolic modulator. It stimulates fat oxidation and improves cellular performance, while having minimal impact on muscle mass or blood sugar levels.
- New generation of biohacking supplements
- For experienced users
- Still not widely available, but highly sought-after
Conclusion
Losing weight in 2025 means relying on personalized solutions based on proven biological mechanisms. These five supplements represent the very best in science, efficacy and sustainability. Before starting any protocol, we recommend that you consult a healthcare professional to adapt the treatment to your profile.
